Diffusion and kurtosis parameters in white matter of premature newborns

TitleDiffusion and kurtosis parameters in white matter of premature newborns
Publication TypeConference Abstract
Year of Publication2011
AuthorsM. Kudzinava, A. Plaisier, J. Dudink, and J. Sijbers
Conference NameWMSG, White Matter Study Group, International Workshop on Advanced White Matter Imaging
Date PublishedAugust
Place PublishedReykjavik, Iceland
Keywordsanisotropy, diffusion, kurtosis, premature newborns, white matter

Diffusion Tensor Imaging (DTI) is often used to study brain maturation processes and white matter (WM) injuries in premature newborns. However, DTI assumes that water diffusion in biological tissues is free. In reality, there is always structural hindrance in WM, which only increases with age due to myelination. Diffusional Kurtosis Imaging (DKI) relaxes the assumption of free diffusion and allows estimation of conventional diffusion parameters plus new kurtosis measures, which are related to tissue complexity. In this work, we present and discuss the first statistics of DKI parameters in WM of two prematurely born infants.