@conference {1545,
	title = {Theoretical study of the free water elimination model},
	volume = {23},
	year = {2015},
	pages = {2757},
	abstract = {Partial volume effects caused by cerebrospinal fluid are an important issue in diffusion MRI. In this work, we study the free water elimination model by analyzing the Cram{\'e}r-Rao lower bound (CRLB) of its parameters. We show that through optimizing the acquisition protocol by minimizing the trace of the CRLB, a significant gain in the precision of the parameter estimation can be achieved. Moreover, further analysis indicates that regularization and/or constraints are necessary for parameter estimation from voxels with large CSF fractions and/or low FA values. These theoretical findings are confirmed by both simulation and real data experiments.},
	author = {Quinten Collier and Jelle Veraart and Ben Jeurissen and Arnold Jan den Dekker and Jan Sijbers}
}
