@conference {1545, title = {Theoretical study of the free water elimination model}, volume = {23}, year = {2015}, pages = {2757}, abstract = {Partial volume effects caused by cerebrospinal fluid are an important issue in diffusion MRI. In this work, we study the free water elimination model by analyzing the Cram{\'e}r-Rao lower bound (CRLB) of its parameters. We show that through optimizing the acquisition protocol by minimizing the trace of the CRLB, a significant gain in the precision of the parameter estimation can be achieved. Moreover, further analysis indicates that regularization and/or constraints are necessary for parameter estimation from voxels with large CSF fractions and/or low FA values. These theoretical findings are confirmed by both simulation and real data experiments.}, author = {Quinten Collier and Jelle Veraart and Ben Jeurissen and Arnold Jan den Dekker and Jan Sijbers} }