@article {CampI.L.N.mverhoyejveraartwvheckeE.S.jsijbersA.avdlinde2011,
	title = {A complementary DTI-histological study in a model of Huntingtons disease},
	journal = {Neurobiology of Aging},
	volume = {33},
	number = {5},
	year = {2012},
	pages = {945-959},
	doi = {http://dx.doi.org/10.1016/j.neurobiolaging.2010.07.001},
	author = {N. Van Camp and Ines Blockx and L. Camon and N. de Vera and Marleen Verhoye and Jelle Veraart and Wim Van Hecke and E. Martinez and Guadelupe S. and Jan Sijbers and A. Planas and Annemie Van Der Linden}
}
@article {1349,
	title = {Identification and characterization of Huntington related pathology: an in vivo DKI imaging study},
	journal = {NeuroImage},
	volume = {63},
	year = {2012},
	month = {09/2012},
	pages = {653-662},
	doi = {http://dx.doi.org/10.1016/j.neuroimage.2012.06.032},
	author = {Ines Blockx and Marleen Verhoye and Johan Van Audekerke and Irene  Bergwerf and Jack X Kane and Rafael  Delgado Y Palacios and Jelle Veraart and Ben Jeurissen and Kerstin Raber and Von H{\"o}rsten, Stephan and Peter Ponsaerts and Jan Sijbers and Trygve B Leergaard and Annemie Van Der Linden}
}
@article {1309,
	title = {Microstructural changes observed with DKI in a transgenic Huntington rat model: Evidence for abnormal neurodevelopment.},
	journal = {NeuroImage},
	volume = {59},
	number = {2},
	year = {2012},
	month = {2012 Jan 16},
	pages = {957-67},
	abstract = {Huntington Disease (HD) is a fatal neurodegenerative disorder, caused by a mutation in the Huntington gene. Although HD is most often diagnosed in mid-life, the key to its clinical expression may be found during brain maturation. In the present work, we performed in vivo diffusion kurtosis imaging (DKI) in order to study brain microstructure alterations in developing transgenic HD rat pups. Several developing brain regions, relevant for HD pathology (caudate putamen, cortex, corpus callosum, external capsule and anterior commissure anterior), were examined at postnatal days 15 (P15) and 30 (P30), and DKI results were validated with histology. At P15, we observed higher mean (MD) and radial (RD) diffusivity values in the cortex of transgenic HD rat pups. In addition, at the age of P30, lower axial kurtosis (AK) values in the caudate putamen of transgenic HD pups were found. At the level of the external capsule, higher MD values at P15 but lower MD and AD values at P30 were detected. The observed DKI results have been confirmed by myelin basic protein immunohistochemistry, which revealed a reduced fiber staining as well as less ordered fibers in transgenic HD rat pups. These results indicate that neuronal development in young transgenic HD rat pups occurs differently compared to controls and that the presence of mutant huntingtin has an influence on postnatal brain development. In this context, various diffusivity parameters estimated by the DKI model are a powerful tool to assess changes in tissue microstructure and detect developmental changes in young transgenic HD rat pups.},
	issn = {1095-9572},
	doi = {10.1016/j.neuroimage.2011.08.062},
	author = {Ines Blockx and G. De Groof and Marleen Verhoye and Johan Van Audekerke and Kerstin Raber and Dirk H J Poot and Jan Sijbers and Osmand, Alexander P and Von H{\"o}rsten, Stephan and Annemie Van Der Linden}
}
@article {jveraartdpootwvheckeBlockxavdlindemverhoyejsijbers2011,
	title = {More accurate estimation of diffusion tensor parameters using diffusion kurtosis imaging},
	journal = {Magnetic Resonance in Medicine},
	volume = {65},
	number = {1},
	year = {2011},
	month = {January},
	pages = {138-145},
	doi = {10.1002/mrm.22603},
	author = {Jelle Veraart and Dirk H J Poot and Wim Van Hecke and Ines Blockx and Annemie Van Der Linden and Marleen Verhoye and Jan Sijbers}
}
@article {jveraartB.T.wvheckeI.bjeurissY.avdlindeA.mverhoyejsijbers2011,
	title = {Population-averaged diffusion tensor imaging atlas of the Sprague Dawley rat brain},
	journal = {NeuroImage},
	volume = {58},
	year = {2011},
	pages = {975-983},
	doi = {10.1016/j.neuroimage.2011.06.063},
	author = {Jelle Veraart and Trygve B Leergaard and Antonsen, Bj{\o}rnar T and Wim Van Hecke and Ines Blockx and Ben Jeurissen and Yi Jiang and Annemie Van Der Linden and Allan G Johnson and Marleen Verhoye and Jan Sijbers}
}
@conference {jveraartAntonsenBlockxwvheckeJiangJohnsonavdlindeLeergaardmverhoyejsijbers2010,
	title = {Construction of a population based diffusion tensor image atlas of the Sprague Dawley rat brain},
	year = {2010},
	month = {May},
	address = {Stockholm, Sweden},
	author = {Jelle Veraart and Antonsen, Bj{\o}rnar T and Ines Blockx and Wim Van Hecke and Yi Jiang and Allan G Johnson and Annemie Van Der Linden and Trygve B Leergaard and Marleen Verhoye and Jan Sijbers}
}
@conference {jveraartwvheckedpootBlockxavdlindemverhoyejsijbers2010,
	title = {A more accurate and b-value independent estimation of diffusion parameters using Diffusion Kurtosis Imaging},
	year = {2010},
	month = {January},
	pages = {10},
	address = {Utrecht, the Netherlands},
	author = {Jelle Veraart and Wim Van Hecke and Dirk H J Poot and Ines Blockx and Annemie Van Der Linden and Marleen Verhoye and Jan Sijbers}
}
@conference {jveraartwvheckedpootBlockxavdlindemverhoyejsijbers2010,
	title = {A more accurate and b-value independent estimation of diffusion parameters using Diffusion Kurtosis Imaging,},
	year = {2010},
	month = {May},
	address = {Stockholm, Sweden},
	author = {Jelle Veraart and Wim Van Hecke and Dirk H J Poot and Ines Blockx and Annemie Van Der Linden and Marleen Verhoye and Jan Sijbers}
}
@inproceedings {jveraartwvheckeBlockxavdlindemverhoyejsijbers2010,
	title = {Non-Rigid coregistration of diffusion kurtosis data},
	booktitle = {Biomedical Imaging: From Nano to Macro, 2010 IEEE International Symposium on},
	year = {2010},
	month = {April},
	pages = {392-395},
	address = {Rotterdam, the Netherlands},
	author = {Jelle Veraart and Wim Van Hecke and Ines Blockx and Annemie Van Der Linden and Marleen Verhoye and Jan Sijbers}
}
@conference {BlockxmverhoyeGroofAudekerkeRaberdpootjsijbersHorstenavdlinde2009,
	title = {Diffusion Kurtosis Imaging (DKI) reveals an early phenotype (P30) in a transgenic rat model for Huntington{\textquoteright}s disease},
	volume = {2009},
	year = {2009},
	month = {April},
	pages = {359},
	author = {Ines Blockx and Marleen Verhoye and G. De Groof and Johan Van Audekerke and Kerstin Raber and Dirk H J Poot and Jan Sijbers and S. von Horsten and Annemie Van Der Linden}
}
@article {1375,
	title = {Diffusion tensor imaging in a rat model of Parkinson{\textquoteright}s disease after lesioning of the nigrostriatal tract.},
	journal = {NMR in biomedicine},
	volume = {22},
	year = {2009},
	month = {2009 Aug},
	pages = {697-706},
	abstract = {Parkinson{\textquoteright}s disease (PD) is characterised by degeneration of the nigrostrial connection causing dramatic changes in the dopaminergic pathway underlying clinical pathology. Till now, no MRI tools were available to follow up any specific PD-related neurodegeneration. However, recently, diffusion tensor imaging (DTI) has received considerable attention as a new and potential in vivo diagnostic tool for various neurodegenerative diseases. To assess this in PD, we performed DTI in the acute 6-hydroxydopamine (6-OHDA) rat model of PD to evaluate diffusion properties in the degenerating nigrostriatal pathway and its connecting structures. Injection of a neurotoxin in the striatum causes retrograde neurodegeneration of the nigrostriatal tract, and selective degeneration of nigral neurons. The advantage of this model is that the lesion size is well controllable by the injected dose of the toxin. The degree of functional impairment was evaluated in vivo using the amphetamine rotation test and microPET imaging of the dopamine transporter (DAT). Despite a nearly complete lesion of the nigrostriatal tract, DTI changes were limited to the ipsilateral substantia nigra (SN). In this study we demonstrate, using voxel-based statistics (VBS), an increase in fractional anisotropy (FA), whereas all eigenvalues were significantly decreased. VBS enabled us to visualise neurodegeneration of a cluster of neurons but failed to detect degeneration of more diffuse microstructures such as the nigrostriatal fibres or the dopaminergic endings in the striatum. VBS without a priori information proved to be better than manual segmentation of brain structures as it does not suffer from volume averaging and is not susceptible to erroneous segmentations of brain regions that show very little contrast on MRI images such as SN.},
	keywords = {Animals, Behavior, Animal, Diffusion Magnetic Resonance Imaging, Disease Models, Animal, Female, Imaging, Three-Dimensional, Immunohistochemistry, Parkinson Disease, Positron-Emission Tomography, Rats, Rats, Wistar, Substantia Nigra},
	issn = {1099-1492},
	doi = {10.1002/nbm.1381},
	author = {N. Van Camp and Ines Blockx and Marleen Verhoye and Casteels, Cindy and Coun, Frea and Alexander Leemans and Jan Sijbers and Veerle Baekelandt and Koen Van Laere and Annemie Van Der Linden}
}
@conference {jveraartBlockxwvheckemverhoyeavdlindejsijbers2009,
	title = {Improved non rigid coregistration of diffusion kurtosis images by incorporating diffusion kurtosis tensor information},
	year = {2009},
	month = {October},
	pages = {36},
	address = {Antalya, Turkey},
	author = {Jelle Veraart and Ines Blockx and Wim Van Hecke and Marleen Verhoye and Annemie Van Der Linden and Jan Sijbers}
}
@conference {dpootajdendekmverhoyeBlockxAudekerkeavdlindejsijbers2009,
	title = {Optimizing the Diffusion Weighting Gradients for Diffusion-Kurtosis Imaging},
	volume = {2009},
	year = {2009},
	month = {April},
	pages = {1394},
	author = {Dirk H J Poot and Arnold Jan den Dekker and Marleen Verhoye and Ines Blockx and Johan Van Audekerke and Annemie Van Der Linden and Jan Sijbers}
}
@inproceedings {CampBlockxCamonVeramverhoyealeemansMartinezjsijbersPlanasavdlinde2006,
	title = {White and grey matters changes in a rat model for Huntington{\textquoteright}s disease discerned with in vivo DTI},
	booktitle = {23rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology},
	year = {2006},
	pages = {210-211},
	address = {Warsaw, Poland},
	author = {N. Van Camp and Ines Blockx and L. Camon and N. de Vera and Marleen Verhoye and Alexander Leemans and E. Martinez and Jan Sijbers and A. Planas and Annemie Van Der Linden}
}
