@article {1516,
	title = {Improved sensitivity to cerebral white matter abnormalities in Alzheimer{\textquoteright}s disease with spherical deconvolution based tractography.},
	journal = {PloS one},
	volume = {7},
	year = {2012},
	month = {2012},
	pages = {e44074},
	abstract = {Diffusion tensor imaging (DTI) based fiber tractography (FT) is the most popular approach for investigating white matter tracts in vivo, despite its inability to reconstruct fiber pathways in regions with "crossing fibers." Recently, constrained spherical deconvolution (CSD) has been developed to mitigate the adverse effects of "crossing fibers" on DTI based FT. Notwithstanding the methodological benefit, the clinical relevance of CSD based FT for the assessment of white matter abnormalities remains unclear. In this work, we evaluated the applicability of a hybrid framework, in which CSD based FT is combined with conventional DTI metrics to assess white matter abnormalities in 25 patients with early Alzheimer{\textquoteright}s disease. Both CSD and DTI based FT were used to reconstruct two white matter tracts: one with regions of "crossing fibers," i.e., the superior longitudinal fasciculus (SLF) and one which contains only one fiber orientation, i.e. the midsagittal section of the corpus callosum (CC). The DTI metrics, fractional anisotropy (FA) and mean diffusivity (MD), obtained from these tracts were related to memory function. Our results show that in the tract with "crossing fibers" the relation between FA/MD and memory was stronger with CSD than with DTI based FT. By contrast, in the fiber bundle where one fiber population predominates, the relation between FA/MD and memory was comparable between both tractography methods. Importantly, these associations were most pronounced after adjustment for the planar diffusion coefficient, a measure reflecting the degree of fiber organization complexity. These findings indicate that compared to conventionally applied DTI based FT, CSD based FT combined with DTI metrics can increase the sensitivity to detect functionally significant white matter abnormalities in tracts with complex white matter architecture.},
	keywords = {Aged, 80 and over, Alzheimer Disease, Cerebrum, Cognition, Corpus Callosum, diffusion tensor imaging, Female, Humans, Male, Memory, Nerve Fibers, Myelinated},
	issn = {1932-6203},
	doi = {10.1371/journal.pone.0044074},
	author = {Reijmer, Yael D and Alexander Leemans and Heringa, Sophie M and Wielaard, Ilse and Ben Jeurissen and Koek, Huiberdina L and Biessels, Geert Jan}
}
@conference {1549,
	title = {Constrained spherical deconvolution based tractography and cognition in Alzheimer{\textquoteright}s disease},
	volume = {5},
	year = {2011},
	address = {Lille, France},
	author = {Reijmer, Yael D and Alexander Leemans and Heringa, Sophie M and Wielaard, Ilse and Ben Jeurissen and Koek, Huiberdina L and Biessels, Geert Jan}
}
@conference {1551,
	title = {Constrained spherical deconvolution based tractography and cognition in Alzheimer{\textquoteright}s disease},
	year = {2011},
	address = {Qu{\'e}bec, Canada},
	author = {Reijmer, Yael D and Alexander Leemans and Heringa, Sophie M and Wielaard, Ilse and Ben Jeurissen and Koek, Huiberdina L and Biessels, Geert Jan}
}
@conference {1552,
	title = {Constrained spherical deconvolution based tractography and cognition in Alzheimer{\textquoteright}s disease},
	year = {2011},
	address = {Paris, France},
	author = {Reijmer, Yael D and Alexander Leemans and Heringa, Sophie M and Wielaard, Ilse and Ben Jeurissen and Koek, Huiberdina L and Biessels, Geert Jan}
}
@conference {1550,
	title = {Diffusion tensor imaging and cognition in Alzheimer{\textquoteright}s disease: the influence of crossing fibers},
	year = {2011},
	address = {Lunteren, The Netherlands},
	author = {Wielaard, Ilse and Reijmer, Yael D and Alexander Leemans and Heringa, Sophie M and Ben Jeurissen and Koek, Huiberdina L and Biessels, Geert Jan}
}
