@article {2087, title = {To Recurse or not to Recurse A Low Dose CT Study}, journal = {Progress in Artificial Intelligence}, volume = {10}, year = {2021}, pages = {65{\textendash}81}, doi = {https://doi.org/10.1007/s13748-020-00224-0}, author = {Shabab Bazrafkan and Vincent Van Nieuwenhove and Joris Soons and Jan De Beenhouwer and Jan Sijbers} } @inproceedings {2068, title = {Ringing Artefact Removal From Sparse View Tomosynthesis using Deep Neural Networks}, booktitle = {The 6th International Conference on Image Formation in X-Ray Computed Tomography}, year = {2020}, pages = {380-383}, author = {Shabab Bazrafkan and Vincent Van Nieuwenhove and Joris Soons and Jan De Beenhouwer and Jan Sijbers} } @article {1644, title = {3D morphometric analysis of the human incudomallear complex using clinical cone-beam CT}, journal = {Hearing research}, volume = {340}, year = {2016}, pages = {79-88}, abstract = {Human middle ears show large morphological variations. This could affect our perception of hearing and explain large variation in experimentally obtained transfer functions. Most morphological studies focus on capturing variation by using landmarks on cadaveric temporal bones. We present statistical shape analysis based on clinical cone beam CT (CBCT) scans of 100 patients. This allowed us to include surface information on the incudomallear (IM) complex (joint, ligaments and tendon not included) of 123 healthy ears with a scanning resolution of 150~μm and without a priori assumptions. Statistical shape modeling yields an average geometry for the IM complex and the variations present in the population with a high precision. Mean values, variation and correlations among anatomical features (length of manubrium, combined length of malleus head and neck, lengths of incus long and short process, enclosing angles, ossicular lever ratio, incudomallear angle, and principal moments of inertia) are reported and compared to results from the literature. Most variation is found in overall size and the angle between incus and malleus. The compact representation provided by statistical shape modeling is demonstrated and its benefits for surface modeling are discussed.}, issn = {1878-5891}, doi = {10.1016/j.heares.2016.01.014}, author = {Joris Soons and Femke Danckaers and Keustermans, William and Toon Huysmans and Jan Sijbers and Casselman, Jan W and Joris J. J. Dirckx} } @conference {1605, title = {Statistical shape modeling of the incudomalleolar complex using micro-CT and clinical cone-beam CT}, year = {2015}, month = {July}, address = {Aalborg, Denmark}, abstract = {Introduction: A large variation in material properties and geometry exists in the human temporal bone. These variations can affect hearing and middle ear sound transmission. Middle ear computer (finite element, FE) models are successfully used to predict sound transmission and its dependence on material properties. The model geometry, however, is mostly based on data of a single sample. Here we use statistical shape models (SSM) to characterize the natural anatomical variations present in the incudomalleolar (IM) complex of humans. SSM can later be used in FE models to study the effect of geometry on sound transmission, or parameters can be fitted to clinical CT data to obtain a patient-specific computer model. Methods and Materials: In this study we combine data of high resolution micro-CT scans (uCT, 20 um resolution) of 6 human cadaveric temporal bones and clinical cone-beam CT scans (CBCT, 150 um resolution) of 100 patients. First, a dense correspondence between the uCT samples is obtained by pair-wise elasticity modulated registration of a reference sample to each of the remaining samples. A SSM is built from these corresponded scans using principal component analysis (PCA), describing the average shape and the main variations of the middle ear within the uCT population. Next this SSM is fitted to clinical CBCT data by elastic registration with the SSM as shape prior. Results and conclusions: We will obtain an average geometrical model for malleus, incus and IM complex and characterize the deviations present in the patient population. We will do this by reporting natural variation of size and thickness of malleus head, neck and manubrium, the long and short process of the incus and relative angles in the IM complex.}, author = {Joris Soons and Femke Danckaers and Toon Huysmans and Jan Sijbers and Jan W. Casselamn and Joris J. J. Dirckx} }