@article {1718,
	title = {High angular resolution diffusion-weighted imaging in mild traumatic brain injury},
	journal = {NeuroImage: Clinical},
	volume = {13},
	year = {2017},
	month = {11/2016},
	pages = {174 - 180},
	abstract = {We sought to investigate white matter abnormalities in mild traumatic brain injury (mTBI) using diffusion-weighted magnetic resonance imaging (DW-MRI). We applied a global approach based on tract-based spatial statistics skeleton as well as constrained spherical deconvolution tractography. DW-MRI was performed on 102 patients with mTBI within two months post-injury and 30 control subjects. A robust global approach considering only the voxels with a single-fiber configuration was used in addition to global analysis of the tract skeleton and probabilistic whole-brain tractography. In addition, we assessed whether the microstructural parameters correlated with age, time from injury, patient{\textquoteright}s outcome and white matter \{MRI\} hyperintensities. We found that whole-brain global approach restricted to single-fiber voxels showed significantly decreased fractional anisotropy (FA) (p = 0.002) and increased radial diffusivity (p = 0.011) in patients with mTBI compared with controls. The results restricted to single-fiber voxels were more significant and reproducible than those with the complete tract skeleton or the whole-brain tractography. \{FA\} correlated with patient outcomes, white matter hyperintensities and age. No correlation was observed between \{FA\} and time of scan post-injury. In conclusion, the global approach could be a promising imaging biomarker to detect white matter abnormalities following traumatic brain injury.},
	keywords = {Diffusion-weighted magnetic resonance imaging, Global approach, Magnetic Resonance Imaging, probabilistic tractography, Traumatic brain injury},
	issn = {2213-1582},
	doi = {http://dx.doi.org/10.1016/j.nicl.2016.11.016},
	url = {http://www.sciencedirect.com/science/article/pii/S2213158216302248},
	author = {Mohammadian, Mehrbod and Timo Roine and Jussi Hirvonen and Timo Kurki and Henna Ala-Sepp{\"a}l{\"a} and Janek Frantz{\'e}n and Ari Katila and Anna Kyll{\"o}nen and Henna-Riikka Maanp{\"a}{\"a} and Jussi Posti and Riikka Takala and Jussi Tallus and Olli Tenovuo}
}
