@article {2074, title = {Macro- and microstructural changes in cosmonauts{\textquoteright} brains after long-duration spaceflight}, journal = {Science Advances}, volume = {6}, year = {2020}, month = {Apr-09-2020}, pages = {eaaz9488}, abstract = {Long-duration spaceflight causes widespread physiological changes, although its effect on brain structure remains poorly understood. In this work, we acquired diffusion magnetic resonance imaging to investigate alterations of white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) compositions in each voxel, before, shortly after, and 7 months after long-duration spaceflight. We found increased WM in the cerebellum after spaceflight, providing the first clear evidence of sensorimotor neuroplasticity. At the region of interest level, this increase persisted 7 months after return to Earth. We also observe a widespread redistribution of CSF, with concomitant changes in the voxel fractions of adjacent GM. We show that these GM changes are the result of morphological changes rather than net tissue loss, which remained unclear from previous studies. Our study provides evidence of spaceflight-induced neuroplasticity to adapt motor strategies in space and evidence of fluid shift{\textendash}induced mechanical changes in the brain.}, doi = {10.1126/sciadv.aaz9488}, url = {https://advances.sciencemag.org/content/6/36/eaaz9488}, author = {Jillings, Steven and Angelique Van Ombergen and Tomilovskaya, Elena and Rumshiskaya, Alena and Litvinova, Liudmila and Nosikova, Inna and Pechenkova, Ekaterina and Rukavishnikov, Ilya and Kozlovskaya, Inessa B. and Manko, Olga and Danilichev, Sergey and Stefan Sunaert and Paul M Parizel and Sinitsyn, Valentin and Petrovichev, Victor and Laureys, Steven and zu Eulenburg, Peter and Jan Sijbers and Floris L Wuyts and Ben Jeurissen} } @article {1964, title = {Alterations of Functional Brain Connectivity After Long-Duration Spaceflight as Revealed by fMRI.}, journal = {Front Physiol}, volume = {10}, year = {2019}, pages = {1-23}, abstract = {

The present study reports alterations of task-based functional brain connectivity in a group of 11 cosmonauts after a long-duration spaceflight, compared to a healthy control group not involved in the space program. To elicit the postural and locomotor sensorimotor mechanisms that are usually most significantly impaired when space travelers return to Earth, a plantar stimulation paradigm was used in a block design fMRI study. The motor control system activated by the plantar stimulation involved the pre-central and post-central gyri, SMA, SII/operculum, and, to a lesser degree, the insular cortex and cerebellum. While no post-flight alterations were observed in terms of activation, the network-based statistics approach revealed task-specific functional connectivity modifications within a broader set of regions involving the activation sites along with other parts of the sensorimotor neural network and the visual, proprioceptive, and vestibular systems. The most notable findings included a post-flight increase in the stimulation-specific connectivity of the right posterior supramarginal gyrus with the rest of the brain; a strengthening of connections between the left and right insulae; decreased connectivity of the vestibular nuclei, right inferior parietal cortex (BA40) and cerebellum with areas associated with motor, visual, vestibular, and proprioception functions; and decreased coupling of the cerebellum with the visual cortex and the right inferior parietal cortex. The severity of space motion sickness symptoms was found to correlate with a post- to pre-flight difference in connectivity between the right supramarginal gyrus and the left anterior insula. Due to the complex nature and rapid dynamics of adaptation to gravity alterations, the post-flight findings might be attributed to both the long-term microgravity exposure and to the readaptation to Earth{\textquoteright}s gravity that took place between the landing and post-flight MRI session. Nevertheless, the results have implications for the multisensory reweighting and gravitational motor system theories, generating hypotheses to be tested in future research.

}, issn = {1664-042X}, doi = {10.3389/fphys.2019.00761}, author = {Pechenkova, Ekaterina and Nosikova, Inna and Rumshiskaya, Alena and Litvinova, Liudmila and Rukavishnikov, Ilya and Mershina, Elena and Valentin Sinitsyn and Angelique Van Ombergen and Ben Jeurissen and Jillings, Steven and Laureys, Steven and Jan Sijbers and Grishin, Alexey and Chernikova, Ludmila and Naumov, Ivan and Kornilova, Ludmila and Floris L Wuyts and Tomilovskaya, Elena and Kozlovskaya, Inessa} } @conference {Wuyts2019-xr, title = {Novel insight on effect and recovery of long-duration spaceflight on the ventricles of the space traveller{\textquoteright}s brain}, volume = {2019}, year = {2019}, pages = {IAC{\textendash}19_A1_2_4_x51230}, publisher = {International Astronautical Federation}, author = {Floris L Wuyts and Jillings, Steven and Angelique Van Ombergen and Ben Jeurissen and Tomilovskaya, Elena and Rumshiskaya, Alena and Litvinova, Liudmila and Nosikova, Inna and Pechenkova, Ekaterina and Rukavishnikov, Ilya and others} }