@article {1402,
	title = {Altered diffusion tensor imaging measurements in aged transgenic Huntington disease rats.},
	journal = {Brain structure \& function},
	volume = {218},
	year = {2013},
	month = {2013 May},
	pages = {767-78},
	abstract = {Rodent models of Huntington disease (HD) are valuable tools for investigating HD pathophysiology and evaluating new therapeutic approaches. Non-invasive characterization of HD-related phenotype changes is important for monitoring progression of pathological processes and possible effects of interventions. The first transgenic rat model for HD exhibits progressive late-onset affective, cognitive, and motor impairments, as well as neuropathological features reflecting observations from HD patients. In this report, we contribute to the anatomical phenotyping of this model by comparing high-resolution ex vivo DTI measurements obtained in aged transgenic HD rats and wild-type controls. By region of interest analysis supplemented by voxel-based statistics, we find little evidence of atrophy in basal ganglia regions, but demonstrate altered DTI measurements in the dorsal and ventral striatum, globus pallidus, entopeduncular nucleus, substantia nigra, and hippocampus. These changes are largely compatible with DTI findings in preclinical and clinical HD patients. We confirm earlier reports that HD rats express a moderate neuropathological phenotype, and provide evidence of altered DTI measures in specific HD-related brain regions, in the absence of pronounced morphometric changes.},
	issn = {1863-2661},
	doi = {10.1007/s00429-012-0427-0},
	author = {Antonsen, Bj{\o}rnar T and Yi Jiang and Jelle Veraart and Qu, Hong and Nguyen, Huu Phuc and Jan Sijbers and Von H{\"o}rsten, Stephan and Allan G Johnson and Trygve B Leergaard}
}
@article {1349,
	title = {Identification and characterization of Huntington related pathology: an in vivo DKI imaging study},
	journal = {NeuroImage},
	volume = {63},
	year = {2012},
	month = {09/2012},
	pages = {653-662},
	doi = {http://dx.doi.org/10.1016/j.neuroimage.2012.06.032},
	author = {Ines Blockx and Marleen Verhoye and Johan Van Audekerke and Irene  Bergwerf and Jack X Kane and Rafael  Delgado Y Palacios and Jelle Veraart and Ben Jeurissen and Kerstin Raber and Von H{\"o}rsten, Stephan and Peter Ponsaerts and Jan Sijbers and Trygve B Leergaard and Annemie Van Der Linden}
}
@article {1309,
	title = {Microstructural changes observed with DKI in a transgenic Huntington rat model: Evidence for abnormal neurodevelopment.},
	journal = {NeuroImage},
	volume = {59},
	number = {2},
	year = {2012},
	month = {2012 Jan 16},
	pages = {957-67},
	abstract = {Huntington Disease (HD) is a fatal neurodegenerative disorder, caused by a mutation in the Huntington gene. Although HD is most often diagnosed in mid-life, the key to its clinical expression may be found during brain maturation. In the present work, we performed in vivo diffusion kurtosis imaging (DKI) in order to study brain microstructure alterations in developing transgenic HD rat pups. Several developing brain regions, relevant for HD pathology (caudate putamen, cortex, corpus callosum, external capsule and anterior commissure anterior), were examined at postnatal days 15 (P15) and 30 (P30), and DKI results were validated with histology. At P15, we observed higher mean (MD) and radial (RD) diffusivity values in the cortex of transgenic HD rat pups. In addition, at the age of P30, lower axial kurtosis (AK) values in the caudate putamen of transgenic HD pups were found. At the level of the external capsule, higher MD values at P15 but lower MD and AD values at P30 were detected. The observed DKI results have been confirmed by myelin basic protein immunohistochemistry, which revealed a reduced fiber staining as well as less ordered fibers in transgenic HD rat pups. These results indicate that neuronal development in young transgenic HD rat pups occurs differently compared to controls and that the presence of mutant huntingtin has an influence on postnatal brain development. In this context, various diffusivity parameters estimated by the DKI model are a powerful tool to assess changes in tissue microstructure and detect developmental changes in young transgenic HD rat pups.},
	issn = {1095-9572},
	doi = {10.1016/j.neuroimage.2011.08.062},
	author = {Ines Blockx and G. De Groof and Marleen Verhoye and Johan Van Audekerke and Kerstin Raber and Dirk H J Poot and Jan Sijbers and Osmand, Alexander P and Von H{\"o}rsten, Stephan and Annemie Van Der Linden}
}
