@article {2270,
	title = {Prolonged microgravity induces reversible and persistent changes on human cerebral connectivity},
	journal = {Communications Biology},
	volume = {6},
	year = {2023},
	doi = {https://doi.org/10.1038/s42003-022-04382-w},
	author = {Steven Jillings and Ekaterina V. Pechenkova and Elena Tomilovskaya and Ilya Rukavishnikov and Ben Jeurissen and Angelique Van Ombergen and Nosikova, Inna and Alena Rumshiskaya and Liudmila Litvinova and Annen, Jitka and Chloe De Laet and Catho Schoenmaekers and Jan Sijbers and Petrovichev, Victor and Stefan Sunaert and Paul M Parizel and Valentin Sinitsyn and zu Eulenburg, P and Steven S L Laureys and Athena Demertzi and Floris L Wuyts}
}
@article {2216,
	title = {Brain Connectometry Changes in Space Travelers After Long-Duration Spaceflight},
	journal = {Front. Neural Circuits},
	volume = {16},
	year = {2022},
	doi = {https://doi.org/10.3389/fncir.2022.815838},
	author = {Andrei Doroshin and Steven Jillings and Ben Jeurissen and Elena Tomilovskaya and Ekaterina V. Pechenkova and Nosikova, Inna and Alena Rumshiskaya and Liudmila Litvinova and Ilya Rukavishnikov and Chloe De Laet and Catho Schoenmaekers and Jan Sijbers and Steven S L Laureys and Petrovichev, Victor and Angelique Van Ombergen and Jitka Annen and Stefan Sunaert and Paul M Parizel and Valentin Sinitsyn and zu Eulenburg, Peter and Karol Osipowicz and Floris L Wuyts}
}
@conference {Jillings2020-nb,
	title = {Diffusion MRI reveals macro- and microstructural changes in cosmonauts{\textquoteright} brains after long-duration spaceflight},
	year = {2020},
	pages = {4531},
	author = {Jillings, S and Angelique Van Ombergen and Tomilovskaya, E and Rumshiskaya, A and Litvinova, L and Nosikova, I and Pechenkova, E and Rukavishnikov, I and Kozlovskaya, I and Stefan Sunaert and Paul M Parizel and Valentin Sinitsyn and Petrovichev, V and Laureys, S and zu Eulenburg, P and Jan Sijbers and Floris L Wuyts and Ben Jeurissen}
}
@article {1971,
	title = {Joint Maximum Likelihood estimation of motion and T1 parameters from magnetic resonance images in a super-resolution framework: a simulation study},
	journal = {Fundamenta Informaticae},
	volume = {172},
	year = {2020},
	pages = {105{\textendash}128},
	abstract = {Magnetic resonance imaging (MRI) based T1 mapping allows spatially resolved quantification of the tissue-dependent spin-lattice relaxation time constant T1, which is a potential biomarker of various neurodegenerative diseases, including Multiple Sclerosis, Alzheimer disease, and Parkinson{\textquoteright}s disease. In conventional T1 MR relaxometry, a quantitative T1 map is obtained from a series of T1-weighted MR images. Acquiring such a series, however, is time consuming. This has sparked the development of more efficient T1 mapping methods, one of which is a super-resolution reconstruction (SRR) framework in which a set of low resolution (LR) T1-weighted images is acquired and from which a high resolution (HR) T1 map is directly estimated. In this paper, the SRR T1 mapping framework is augmented with motion estimation. That is, motion between the acquisition of the LR T1-weighted images is modeled and the motion parameters are estimated simultaneously with the T1 parameters. Based on Monte Carlo simulation experiments, we show that such an integrated motion/relaxometry estimation approach yields more accurate T1 maps compared to a previously reported SRR based T1 mapping approach.},
	doi = {10.3233/FI-2020-1896},
	author = {Quinten Beirinckx and Gabriel Ramos-Llord{\'e}n and Ben Jeurissen and Dirk H J Poot and Paul M Parizel and Marleen Verhoye and Jan Sijbers and Arnold Jan den Dekker}
}
@article {2074,
	title = {Macro- and microstructural changes in cosmonauts{\textquoteright} brains after long-duration spaceflight},
	journal = {Science Advances},
	volume = {6},
	year = {2020},
	month = {Apr-09-2020},
	pages = {eaaz9488},
	abstract = {Long-duration spaceflight causes widespread physiological changes, although its effect on brain structure remains poorly understood. In this work, we acquired diffusion magnetic resonance imaging to investigate alterations of white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) compositions in each voxel, before, shortly after, and 7 months after long-duration spaceflight. We found increased WM in the cerebellum after spaceflight, providing the first clear evidence of sensorimotor neuroplasticity. At the region of interest level, this increase persisted 7 months after return to Earth. We also observe a widespread redistribution of CSF, with concomitant changes in the voxel fractions of adjacent GM. We show that these GM changes are the result of morphological changes rather than net tissue loss, which remained unclear from previous studies. Our study provides evidence of spaceflight-induced neuroplasticity to adapt motor strategies in space and evidence of fluid shift{\textendash}induced mechanical changes in the brain.},
	doi = {10.1126/sciadv.aaz9488},
	url = {https://advances.sciencemag.org/content/6/36/eaaz9488},
	author = {Jillings, Steven and Angelique Van Ombergen and Tomilovskaya, Elena and Rumshiskaya, Alena and Litvinova, Liudmila and Nosikova, Inna and Pechenkova, Ekaterina and Rukavishnikov, Ilya and Kozlovskaya, Inessa B. and Manko, Olga and Danilichev, Sergey and Stefan Sunaert and Paul M Parizel and Valentin Sinitsyn and Petrovichev, Victor and Laureys, Steven and zu Eulenburg, Peter and Jan Sijbers and Floris L Wuyts and Ben Jeurissen}
}
@article {1941,
	title = {Brain ventricular volume changes induced by long-duration spaceflight},
	journal = {Proceedings of the National Academy of Sciences},
	volume = {116},
	year = {2019},
	pages = {10531-10536},
	abstract = {Long-duration spaceflight induces detrimental changes in human physiology due to microgravity. One example is a cephalic fluid shift. Here, we prospectively investigated the quantitative changes in cerebrospinal fluid (CSF) volume of the brain ventricular regions in space crew by means of a region of interest, observer-independent analysis on structural brain MRI scans. MRI scans were collected before the mission, shortly after and 7 mo after return to Earth. We found a significant increase in lateral and third ventricles at postflight and a trend to normalization at follow-up, but still significantly increased ventricular volumes. The observed spatiotemporal pattern of CSF compartment enlargement and recovery points to a reduced CSF resorption in microgravity as the underlying cause.Long-duration spaceflight induces detrimental changes in human physiology. Its residual effects and mechanisms remain unclear. We prospectively investigated the changes in cerebrospinal fluid (CSF) volume of the brain ventricular regions in space crew by means of a region of interest analysis on structural brain scans. Cosmonaut MRI data were investigated preflight (n = 11), postflight (n = 11), and at long-term follow-up 7 mo after landing (n = 7). Post hoc analyses revealed a significant difference between preflight and postflight values for all supratentorial ventricular structures, i.e., lateral ventricle (mean \% change {\textpm} SE = 13.3 {\textpm} 1.9), third ventricle (mean \% change {\textpm} SE = 10.4 {\textpm} 1.1), and the total ventricular volume (mean \% change {\textpm} SE = 11.6 {\textpm} 1.5) (all P \&lt; 0.0001), with higher volumes at postflight. At follow-up, these structures did not quite reach baseline levels, with still residual increases in volume for the lateral ventricle (mean \% change {\textpm} SE = 7.7 {\textpm} 1.6; P = 0.0009), the third ventricle (mean \% change {\textpm} SE = 4.7 {\textpm} 1.3; P = 0.0063), and the total ventricular volume (mean \% change {\textpm} SE = 6.4 {\textpm} 1.3; P = 0.0008). This spatiotemporal pattern of CSF compartment enlargement and recovery points to a reduced CSF resorption in microgravity as the underlying cause. Our results warrant more detailed and longer longitudinal follow-up. The clinical impact of our findings on the long-term cosmonauts{\textquoteright} health and their relation to ocular changes reported in space travelers requires further prospective studies.},
	issn = {0027-8424},
	doi = {10.1073/pnas.1820354116},
	url = {https://www.pnas.org/content/early/2019/05/01/1820354116},
	author = {Angelique Van Ombergen and Steven Jillings and Ben Jeurissen and Tomilovskaya, Elena and Alena Rumshiskaya and Liudmila Litvinova and Nosikova, Inna and Ekaterina V. Pechenkova and Ilya Rukavishnikov and Manko, Olga and Danylichev, Sergey and R{\"u}hl, R. Maxine and Inessa B. Kozlovskaya and Stefan Sunaert and Paul M Parizel and Valentin Sinitsyn and Steven S L Laureys and Jan Sijbers and zu Eulenburg, Peter and Floris L Wuyts}
}
@article {1908,
	title = {Brain Tissue{\textendash}Volume Changes in Cosmonauts},
	journal = {New England Journal of Medicine},
	volume = {379},
	year = {2018},
	pages = {1678 - 1680},
	issn = {0028-4793},
	doi = {10.1056/NEJMc1809011},
	url = {http://www.nejm.org/doi/10.1056/NEJMc1809011},
	author = {Angelique Van Ombergen and Steven Jillings and Ben Jeurissen and Tomilovskaya, Elena and R{\"u}hl, Maxine and Alena Rumshiskaya and Nosikova, Inna and Liudmila Litvinova and Annen, Jitka and Ekaterina V. Pechenkova and Inessa B. Kozlovskaya and Stefan Sunaert and Paul M Parizel and Valentin Sinitsyn and Steven S L Laureys and Jan Sijbers and zu Eulenburg, Peter and Floris L Wuyts}
}
@conference {1949,
	title = {Changes in intrinsic functional brain connectivity after first-time exposure to parabolic flight},
	year = {2018},
	doi = {10.3389/conf.fphys.2018.26.00017},
	author = {Angelique Van Ombergen and Floris L Wuyts and Ben Jeurissen and Jan Sijbers and Floris Vanhevel and Steven Jillings and Paul M Parizel and Stefan Sunaert and Paul H Van de Heyning and Vincent Dousset and Steven S L Laureys and Athena Demertzi}
}
@article {1820,
	title = {Diffusion kurtosis imaging with free water elimination: a Bayesian estimation approach},
	journal = {Magnetic Resonance in Medicine},
	volume = {80},
	year = {2018},
	pages = {802-813},
	doi = {10.1002/mrm.27075},
	author = {Quinten Collier and Jelle Veraart and Ben Jeurissen and Floris Vanhevel and Pim Pullens and Paul M Parizel and Arnold Jan den Dekker and Jan Sijbers}
}
@article {1842,
	title = {NOVIFAST: A fast algorithm for accurate and precise VFA MRI T1 mapping},
	journal = {IEEE Transactions on Medical Imaging},
	volume = {37},
	year = {2018},
	pages = {2414 - 2427},
	doi = {10.1109/TMI.2018.2833288},
	author = {Gabriel Ramos-Llord{\'e}n and Gonzalo Vegas-S{\'a}nchez-Ferrero and Marcus Bj{\"o}rk and Floris Vanhevel and Paul M Parizel and Raul San Jos{\'e} Est{\'e}par and Arnold Jan den Dekker and Jan Sijbers}
}
@conference {Jeurissen2018-zz,
	title = {Super-resolution for spherical deconvolution of multi-shell diffusion MRI data},
	year = {2018},
	pages = {36},
	author = {Ben Jeurissen and Ramos-Llord{\'e}n, Gabriel and Floris Vanhevel and Paul M Parizel and Jan Sijbers}
}
@conference {Van_Dyck2018-st,
	title = {Super-resolution Reconstruction of Knee MRI},
	year = {2018},
	pages = {5184},
	author = {Pieter Van Dyck and Floris Vanhevel and De Smet, E and Paul M Parizel and Jan Sijbers and Ben Jeurissen}
}
@article {1752,
	title = {Altered functional brain connectivity in patients with visually induced dizziness},
	journal = {NeuroImage: Clinical},
	volume = {14},
	year = {2017},
	pages = {538{\textendash}545},
	doi = {http://dx.doi.org/10.1016/j.nicl.2017.02.020},
	author = {Angelique Van Ombergen and Lizette Heine and Steven Jillings and Edward Roberts and Ben Jeurissen and V. Van Rompaey and Viviana Mucci and Stefanie Vanhecke and Jan Sijbers and Floris Vanhevel and Stefan Sunaert and Mohamed Ali Bahri and Paul M Parizel and Paul H Van de Heyning and Steven S L Laureys and Floris L Wuyts}
}
@article {1789,
	title = {Can portable tomosynthesis improve the diagnostic value of bedside chest X-ray in the intensive care unit? A proof of concept study},
	journal = {European Radiology Experimental},
	volume = {1},
	year = {2017},
	pages = {1-7},
	doi = {10.1186/s41747-017-0021-6},
	author = {Jeroen Cant and Annemie Snoeckx and Gert Behiels and Paul M Parizel and Jan Sijbers}
}
@conference {Van_Dyck2017-jo,
	title = {Diffusion Tensor Imaging of the Anterior Cruciate Ligament Graft},
	year = {2017},
	pages = {377},
	author = {Pieter Van Dyck and De Smet, Eline and Froeling, Martijn and Verdonk, Peter and Torfs, Micha{\"e}l and Pim Pullens and Jan Sijbers and Paul M Parizel and Ben Jeurissen}
}
@article {1744,
	title = {Diffusion Tensor Imaging of the Anterior Cruciate Ligament Graft},
	journal = {Journal of Magnetic Resonance Imaging},
	volume = {46},
	year = {2017},
	pages = {1423{\textendash}1432},
	doi = {10.1002/jmri.25666},
	author = {Pieter Van Dyck and Martijn Froeling and Eline De Smet and Pim Pullens and Micha{\"e}l Torfs and Peter Verdonck and Jan Sijbers and Paul M Parizel and Ben Jeurissen}
}
@article {1756,
	title = {The effect of spaceflight and microgravity on the human brain},
	journal = {Journal of Neurology},
	volume = {246},
	year = {2017},
	pages = {18-22},
	doi = {10.1007/s00415-017-8427-x},
	author = {Angelique Van Ombergen and Athena Demertzi and Elena Tomilovskaya and Ben Jeurissen and Jan Sijbers and Inessa B. Kozlovskaya and Paul M Parizel and Paul H Van de Heyning and Stefan Sunaert and Steven S L Laureys and Floris L Wuyts}
}
@conference {Giraldo2017-nq,
	title = {Fixel-Based Analysis of Alzheimer{\textquoteright}s Disease Using Multi-Tissue Constrained Spherical Deconvolution of Multi-Shell Diffusion MRI},
	year = {2017},
	pages = {400},
	author = {Diana Giraldo and Struyfs, Hanne and Raffelt, David and Paul M Parizel and Sebastiaan Engelborghs and Romero, Eduardo and Jan Sijbers and Ben Jeurissen}
}
@article {1762,
	title = {Intrinsic connectivity reduces in vestibular-related regions after first-time exposure to short-term gravitational alterations},
	journal = {Scientific Reports},
	volume = {7},
	year = {2017},
	doi = {10.1038/s41598-017-03170-5},
	author = {Angelique Van Ombergen and Floris L Wuyts and Ben Jeurissen and Jan Sijbers and Floris Vanhevel and Steven Jillings and Paul M Parizel and Stefan Sunaert and Paul H Van de Heyning and Vincent Dousset and Steven S L Laureys and Athena Demertzi}
}
@article {1723,
	title = {A safe, cheap and easy-to-use isotropic diffusion phantom for clinical and multicenter studies},
	journal = {Medical Physics},
	volume = {44},
	year = {2017},
	pages = {1063{\textendash}1070},
	doi = {10.1002/mp.12101},
	author = {Pim Pullens and Piet Bladt and Jan Sijbers and Andrew I.R. Maas and Paul M Parizel}
}
@conference {1764,
	title = {Solving the Free Water Elimination Estimation Problem by Incorporating T2 Relaxation Properties},
	year = {2017},
	author = {Quinten Collier and Jelle Veraart and Arnold Jan den Dekker and Floris Vanhevel and Paul M Parizel and Jan Sijbers}
}
@article {1668,
	title = {Super-resolution T1 estimation: quantitative high resolution T1 mapping from a set of low resolution T1 weighted images with different slice orientations},
	journal = {Magnetic Resonance in Medicine},
	volume = {77},
	year = {2017},
	pages = {1818{\textendash}1830},
	doi = {10.1002/mrm.26262},
	author = {Gwendolyn Van Steenkiste and Dirk H J Poot and Ben Jeurissen and Arnold Jan den Dekker and Floris Vanhevel and Paul M Parizel and Jan Sijbers}
}
@article {1584,
	title = {Cortical reorganization in an astronaut{\textquoteright}s brain after long-duration spaceflight},
	journal = {Brain Structure and Function},
	volume = {221},
	year = {2016},
	pages = {2873{\textendash}2876},
	doi = {10.1007/s00429-015-1054-3},
	author = {Athena Demertzi and Angelique Van Ombergen and Elena Tomilovskaya and Ben Jeurissen and Ekaterina V. Pechenkova and Carol Di Perri and Liudmila Litvinova and Enrico Amico and Alena Rumshiskaya and Ilya Rukavishnikov and Jan Sijbers and Valentin Sinitsyn and Inessa B. Kozlovskaya and Stefan Sunaert and Paul M Parizel and Paul H Van de Heyning and Steven S L Laureys and Floris L Wuyts}
}
@article {1536,
	title = {Super-resolution reconstruction of diffusion parameters from diffusion-weighted images with different slice orientations},
	journal = {Magnetic Resonance in Medicine},
	volume = {75},
	year = {2016},
	pages = {181-195},
	doi = {10.1002/mrm.25597},
	url = {http://onlinelibrary.wiley.com/doi/10.1002/mrm.25597/abstract},
	author = {Gwendolyn Van Steenkiste and Ben Jeurissen and Jelle Veraart and Arnold Jan den Dekker and Paul M Parizel and Dirk H J Poot and Jan Sijbers}
}
@article {1604,
	title = {Diffusion Kurtosis Imaging: a possible MRI biomarker for AD diagnosis?},
	journal = {Journal of Alzheimer{\textquoteright}s Disease},
	volume = {48},
	number = {4},
	year = {2015},
	pages = {937-948},
	doi = {10.3233/JAD-150253},
	author = {Hanna Struyfs and Wim Van Hecke and Jelle Veraart and Jan Sijbers and Sylvie Slaets and Maya De Belder and Laura Wuyts and Benjamin Peters and Kristel Sleegers and Caroline Robberecht and Van Broeckhoven, Christine and Frank De Belder and Paul M Parizel and Sebastiaan Engelborghs}
}
@article {1517,
	title = {Evaluation of an anthropometric shape model of the human scalp},
	journal = {Applied Ergonomics},
	volume = {48},
	year = {2015},
	pages = {70-85},
	doi = {10.1016/j.apergo.2014.11.008},
	author = {Daniel Lacko and Toon Huysmans and Paul M Parizel and Guido De Bruyne and Stijn Verwulgen and Marc M. Van Hulle and Jan Sijbers}
}
@conference {Van_Ombergen2015-nk,
	title = {A first insight in regional brain changes after parabolic flight: a voxel-based morphometry study},
	year = {2015},
	pages = {1258},
	author = {Angelique Van Ombergen and Ben Jeurissen and Floris Vanhevel and Loeckx, Dirk and Dousset, Vincent and Paul M Parizel and Floris L Wuyts}
}
@conference {1482,
	title = {Super-resolution reconstruction of diffusion parameters from multi-oriented diffusion weighted images},
	year = {2014},
	month = {january},
	address = {Maastricht, The Netherlands},
	author = {Gwendolyn Van Steenkiste and Ben Jeurissen and Dirk H J Poot and Paul M Parizel and Jan Sijbers}
}
@conference {1483,
	title = {Super-resolution reconstruction of diffusion parameters from multi-oriented diffusion weighted images},
	year = {2014},
	month = {May},
	address = {Milan, Italy},
	author = {Gwendolyn Van Steenkiste and Ben Jeurissen and Paul M Parizel and Dirk H J Poot and Jan Sijbers}
}
@article {1361,
	title = {Does the use of hormonal contraceptives cause microstructural changes in cerebral white matter? Preliminary results of a DTI and tractography study.},
	journal = {European radiology},
	volume = {23},
	year = {2013},
	month = {2012 Jul 20},
	pages = {57-64},
	abstract = {OBJECTIVE: To evaluate the effect of monophasic combined oral contraceptive pill (COCP) and menstrual cycle phase in healthy young women on white matter (WM) organization using diffusion tensor imaging (DTI). METHODS: Thirty young women were included in the study; 15 women used COCP and 15 women had a natural cycle. All subjects underwent DTI magnetic resonance imaging during the follicular and luteal phase of their cycle, or in different COCP cycle phases. DTI parameters were obtained in different WM structures by performing diffusion tensor fibre tractography. Fractional anisotropy and mean diffusivity were calculated for different WM structures. Hormonal plasma concentrations were measured in peripheral venous blood samples and correlated with the DTI findings. RESULTS: We found a significant difference in mean diffusivity in the fornix between the COCP and the natural cycle group. Mean diffusivity values in the fornix were negatively correlated with luteinizing hormone and estradiol blood concentrations. CONCLUSION: An important part in the limbic system, the fornix, regulates emotional processes. Differences in diffusion parameters in the fornix may contribute to behavioural alternations related to COCP use. This finding also suggests that the use of oral contraceptives needs to be taken into account when designing DTI group studies. KEY POINTS: {\textbullet} Diffusion tensor MRI offers new insights into brain white matter microstructure. {\textbullet} The effects of oral hormonal contraception were examined in young women. {\textbullet} Diffusion tensor images and hormone blood concentrations were evaluated. {\textbullet} Women using hormonal contraception demonstrated higher mean diffusivity in the fornix. {\textbullet} These changes may contribute to behavioural alternations related to contraception use.},
	issn = {1432-1084},
	doi = {10.1007/s00330-012-2572-5},
	author = {De Bondt, Timo and Wim Van Hecke and Jelle Veraart and Alexander Leemans and Jan Sijbers and Stefan Sunaert and Jacquemyn, Yves and Paul M Parizel}
}
@article {1470,
	title = {Regional gray matter volume differences and sex-hormone correlations as a function of menstrual cycle phase and hormonal contraceptives use.},
	journal = {Brain research},
	volume = {1530},
	year = {2013},
	month = {2013 Sep 12},
	pages = {22-31},
	abstract = {During the menstrual cycle, hormone-driven functional and morphological changes occur in the female brain. The influence of hormonal contraceptives on these changes has received only little attention in the medical literature. The purpose of our study is to measure regional gray matter volume changes as a function of the cycle phase and use of hormonal contraceptives, in relation to blood concentrations of sex hormones. We performed a prospective study in 30 healthy young women; 15 women had a natural menstrual cycle and 15 were using monophasic combined hormonal contraceptives. MRI examinations were acquired at 2 specific time-points in the cycle (follicular and luteal phase). MRI studies included a T1-weighted, isotropic, high-resolution 3-D gradient echo acquisition, for the purpose of performing voxel based morphometry. Peripheral venous blood samples were obtained to determine concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol, and progesterone. We found a highly significant negative correlation of regional gray matter volume in the anterior cingulate cortex with estradiol concentrations. To the best of our knowledge, this result has not been described before, and was only present in the natural cycle group, not in women using hormonal contraceptives. The anterior cingulate cortex is involved in emotion processing and there is literature describing behavioral alternations with changing hormone levels. Our findings provide a structural, morphological basis to support these data. Therefore, we advise neuroscientists to take into account the menstrual cycle phase and use of hormonal contraceptives, in order to avoid obtaining heterogeneous data sets, leading to a significant loss of accuracy and precision.},
	issn = {1872-6240},
	doi = {10.1016/j.brainres.2013.07.034},
	author = {De Bondt, Timo and Jacquemyn, Y and Wim Van Hecke and Jan Sijbers and Stefan Sunaert and Paul M Parizel}
}
@article {1328,
	title = {Super-Resolution for Multislice Diffusion Tensor Imaging},
	journal = {Magnetic Resonance in Medicine},
	volume = {69},
	year = {2013},
	pages = {103{\textendash}113},
	abstract = {Diffusion weighted (DW) magnetic resonance images are often recorded with single shot multislice
imaging sequences, because of their short scanning times and robustness to motion. To minimize
noise and acquisition time, images are generally acquired with either anisotropic or isotropic
low resolution voxels, which impedes subsequent posterior image processing and visualization. In
this paper, we propose a super-resolution method for diffusion weighted imaging that combines
anisotropic multislice images to enhance the spatial resolution of diffusion tensor (DT) data. Each
DW image is reconstructed from a set of arbitrarily oriented images with a low through-plane
resolution. The quality of the reconstructed DW images was evaluated by DT metrics and tractography.
Experiments with simulated data, a hardware DTI phantom, as well as in vivo human
brain data were conducted. Our results show a significant increase in spatial resolution of the DT
data while preserving high signal to noise ratio.},
	doi = {10.1002/mrm.24233},
	author = {Dirk H J Poot and Ben Jeurissen and Yannick Bastiaensen and Jelle Veraart and Wim Van Hecke and Paul M Parizel and Jan Sijbers}
}
@inproceedings {1299,
	title = {Quantitative evaluation of ASiR image quality: an adaptive statistical iterative reconstruction technique},
	booktitle = {SPIE Medical Imaging},
	volume = {8313},
	year = {2012},
	month = {02/2012},
	abstract = {Adaptive statistical iterative reconstruction (ASiR) is a new algorithm used in medical X-ray imaging. It combines the standard FBP and the strength of iterative reconstruction by including a noise model in the reconstruction scheme. In this paper the effect of ASiR on the contrast to noise ratio (CNR) is studied using a low contrast phantom (Catphan). The experiments were done at different voltages and currents. The results show reduced noise and increased contrast for the ASiR reconstructions compared to FBP. For the same CNR the images from ASiR are obtained using 60\% less current, leading to a 60\% dose reduction.},
	doi = {doi:10.1117/12.911283},
	author = {Elke Van de Casteele and Paul M Parizel and Jan Sijbers}
}
@conference {1365,
	title = {Statistical shape modelling in support of user-centred BCI headset design},
	year = {2012},
	author = {Daniel Lacko and Toon Huysmans and Stijn Verwulgen and Paul M Parizel and Marc M. Van Hulle and Jan Sijbers}
}
@inbook {1263,
	title = {Classification of Soft Tissue Tumors by Machine Learning Algorithms},
	booktitle = {Soft Tissue Tumors},
	year = {2011},
	publisher = {InTech},
	organization = {InTech},
	issn = {978-953-307-862-5},
	author = {Juntu, Jaber and Arthur M. De Schepper and Pieter Van Dyck and Dirk Van Dyck and Jan L Gielen and Paul M Parizel and Jan Sijbers}
}
@article {wvheckeAleemanssdbackerBjeurisspmparizejsijbers2010,
	title = {Comparing isotropic and anisotropic smoothing for voxel-based DTI analyses: A simulation study},
	journal = {Human Brain Mapping},
	volume = {31},
	number = {1},
	year = {2010},
	pages = {98-114},
	author = {Wim Van Hecke and Alexander Leemans and Steve De Backer and Ben Jeurissen and Paul M Parizel and Jan Sijbers}
}
@article {wvheckeNagelsaleemansVandervlietjsijbersParizel2010,
	title = {Correlation of cognitive dysfunction and diffusion tensor MRI measures in patients with mild and moderate multiple sclerosis},
	journal = {Journal of magnetic resonance imaging},
	volume = {31},
	number = {6},
	year = {2010},
	month = {May},
	pages = {1492-1498},
	author = {Wim Van Hecke and Guy Nagels and Alexander Leemans and Everhard Vandervliet and Jan Sijbers and Paul M Parizel}
}
@article {wvheckejsijberssdbackerdpootParizelaleemans2009,
	title = {On the construction of a ground truth framework for evaluating voxel-based diffusion tensor MRI analysis methods},
	journal = {NeuroImage},
	volume = {46},
	number = {3},
	year = {2009},
	month = {July},
	pages = {692-707},
	doi = {10.1016/j.neuroimage.2008.07.006},
	author = {Wim Van Hecke and Jan Sijbers and Steve De Backer and Dirk H J Poot and Paul M Parizel and Alexander Leemans}
}
@article {1376,
	title = {A diffusion tensor imaging group study of the spinal cord in multiple sclerosis patients with and without T2 spinal cord lesions.},
	journal = {Journal of magnetic resonance imaging : JMRI},
	volume = {30},
	year = {2009},
	month = {2009 Jul},
	pages = {25-34},
	abstract = {PURPOSE: To examine the T(2)-normal appearing spinal cord of patients with multiple sclerosis (MS) using diffusion tensor imaging.

MATERIALS AND METHODS: Diffusion tensor images of the spinal cord were acquired from 21 healthy subjects, 11 MS patients with spinal cord lesions, and 10 MS patients without spinal cord lesions on the T(2)-weighted MR images. Different diffusion measures were evaluated using both a region of interest (ROI) -based and a diffusion tensor tractography-based segmentation approach.

RESULTS: It was observed that the FA, the transverse diffusivity lambda(perpendicular), and the ratio of the longitudinal and transverse diffusivities (lambda(parallel)/lambda (perpendicular)) were significantly lower in the spinal cord of MS patients with spinal cord lesions compared with the control subjects using both the ROI method (P = 0.014, P = 0.028, and P = 0.039, respectively) and the tractography-based approach (P = 0.006, P = 0.037, and P = 0.012, respectively). For both image analysis methods, the FA and the lambda (parallel)/lambda (perpendicular) values were significantly different between the control group and the MS patient group without T(2) spinal cord lesions (P = 0.013).

CONCLUSION: Our results suggest that the spinal cord may still be affected by MS, even when lesions are not detected on a conventional MR scan. In addition, we demonstrated that diffusion tensor tractography is a robust tool to analyze the spinal cord of MS patients.},
	keywords = {Adult, Analysis of Variance, anisotropy, Diffusion Magnetic Resonance Imaging, Female, Humans, Image Processing, Computer-Assisted, Male, Multiple Sclerosis, Observer Variation, Reproducibility of Results, Spinal Cord, Spinal Cord Diseases, Thoracic Vertebrae},
	issn = {1053-1807},
	doi = {10.1002/jmri.21817},
	author = {Wim Van Hecke and Guy Nagels and Emonds, Griet and Alexander Leemans and Jan Sijbers and van Goethem, Johan and Paul M Parizel}
}
@mastersthesis {1271,
	title = {Improved Processing for Diffusion Tensor Magnetic Resonance Images for Coregistration, Atlas Construction, and Voxel Based Analysis},
	year = {2009},
	school = {University of Antwerp},
	type = {PhD thesis},
	address = {Antwerp},
	author = {Wim Van Hecke}
}
@article {1374,
	title = {Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis: revisited.},
	journal = {Human brain mapping},
	volume = {30},
	year = {2009},
	month = {2009 Nov},
	pages = {3657-75},
	abstract = {Voxel-based analyses (VBA) are increasingly being used to detect white matter abnormalities with diffusion tensor imaging (DTI) in different types of pathologies. However, the validity, specificity, and sensitivity of statistical inferences of group differences to a large extent depend on the quality of the spatial normalization of the DTI images. Using high-dimensional nonrigid coregistration techniques that are able to align both the spatial and orientational diffusion information and incorporate appropriate templates that contain this complete DT information may improve this quality. Alternatively, a hybrid technique such as tract-based spatial statistics (TBSS) may improve the reliability of the statistical results by generating voxel-wise statistics without the need for perfect image alignment and spatial smoothing. In this study, we have used (1) a coregistration algorithm that was optimized for coregistration of DTI data and (2) a population-based DTI atlas to reanalyze our previously published VBA, which compared the fractional anisotropy and mean diffusivity maps of patients with amyotrophic lateral sclerosis (ALS) with those of healthy controls. Additionally, we performed a complementary TBSS analysis to improve our understanding and interpretation of the VBA results. We demonstrate that, as the overall variance of the diffusion properties is lowered after normalizing the DTI data with such recently developed techniques (VBA using our own optimized high-dimensional nonrigid coregistration and TBSS), more reliable voxel-wise statistical results can be obtained than had previously been possible, with our VBA and TBSS yielding very similar results. This study provides support for the view of ALS as a multisystem disease, in which the entire frontotemporal lobe is implicated.},
	keywords = {Adult, Aged, Algorithms, Amyotrophic Lateral Sclerosis, anisotropy, Brain, Brain Mapping, Case-Control Studies, diffusion tensor imaging, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Reproducibility of Results, Sensitivity and Specificity, Statistics as Topic},
	issn = {1097-0193},
	doi = {10.1002/hbm.20794},
	author = {Caroline A Sage and Wim Van Hecke and Ron R Peeters and Jan Sijbers and Robberecht, Wim and Paul M Parizel and Marchal, Guy and Alexander Leemans and Stefan Sunaert}
}
@inproceedings {wvheckealeemanssdbackerParizeljsijbers2008,
	title = {On the construction of a ground truth methodology to evaluate VBM analysis results of diffusion tensor images},
	booktitle = {European Society for Magnetic Resonance in Medicine and Biology},
	year = {2008},
	month = {October},
	address = {Valencia, Spain},
	author = {Wim Van Hecke and Alexander Leemans and Steve De Backer and Paul M Parizel and Jan Sijbers}
}
@article {wvheckejsijbersDagostinoMaessdbackerVandervlietParizelaleemans2008,
	title = {On the construction of an inter-subject diffusion tensor magnetic resonance atlas of the healthy human brain},
	journal = {NeuroImage},
	volume = {43},
	number = {1},
	year = {2008},
	pages = {69-80},
	doi = {0.1016/j.neuroimage.2008.07.006},
	author = {Wim Van Hecke and Jan Sijbers and E. Dagostino and F. Maes and Steve De Backer and Everhard Vandervliet and Paul M Parizel and Alexander Leemans}
}
@inproceedings {wvheckejsijbersGoethemParizel2008,
	title = {Diffusion tensor tractography reveals white matter alterations in the normal appearing spinal cord of Multiple Sclerosis patients},
	booktitle = {European Society for Magnetic Resonance in Medicine and Biology},
	year = {2008},
	month = {October},
	address = {Valencia, Spain},
	author = {Wim Van Hecke and Jan Sijbers and J. Van Goethem and Paul M Parizel}
}
@inproceedings {wvheckealeemansAgostinosdbackerVandervlietParizeljsijbers2008,
	title = {The evaluation of a population based diffusion tensor image atlas using a ground truth method},
	booktitle = {Proceedings of SPIE Medical Imaging},
	volume = {6914},
	year = {2008},
	month = {February},
	address = {San Diego, USA},
	author = {Wim Van Hecke and Alexander Leemans and E. Dagostino and Steve De Backer and Everhard Vandervliet and Paul M Parizel and Jan Sijbers}
}
@conference {thuysmanBernatrpinhojsijbersGlabbeeckParizelBortier2008,
	title = {A Framework for Morphometric Analysis of Long Bones: Application to the Human Clavicle},
	year = {2008},
	month = {March},
	author = {Toon Huysmans and Amit Bernat and R{\^o}mulo Pinho and Jan Sijbers and Francis Van Glabbeek and Paul M Parizel and H. Bortier}
}
@conference {wvheckealeemanssdbackerVandervlietjsijberspmparize2008,
	title = {A Ground Truth Analysis of the Preservation of Diffusion Tensor Information in a Population Specific Atlas},
	year = {2008},
	month = {May},
	address = {Toronto, Canada},
	author = {Wim Van Hecke and Alexander Leemans and Steve De Backer and Everhard Vandervliet and Jan Sijbers and Paul M Parizel}
}
@article {wvheckealeemansjsijbersVandervlietGoethemParizel2008,
	title = {A tracking based DTI segmentation method for the detection of diffusion-related changes of the cervical spinal cord with aging},
	journal = {Journal of Magnetic Resonance Imaging},
	volume = {27},
	number = {5},
	year = {2008},
	month = {March},
	pages = {978-991},
	doi = {10.1002/jmri.21338},
	author = {Wim Van Hecke and Alexander Leemans and Jan Sijbers and Everhard Vandervliet and J. Van Goethem and Paul M Parizel}
}
@inproceedings {wvheckeDagostinoaleemansParizelMaesjsijbers2007,
	title = {On the construction of a healthy brain inter-subject diffusion tensor image and tractography atlas},
	booktitle = {32nd Congress of the Europea Society of NeuroRadiolog},
	year = {2007},
	pages = {146},
	author = {Wim Van Hecke and E. Dagostino and Alexander Leemans and Paul M Parizel and F. Maes and Jan Sijbers}
}
@inproceedings {wvheckealeemansBrabanderLaridonClaeysCeulemansGoethemParizeljsijbers2007,
	title = {Diffusion Tensor Fiber Tracking Reveals Probst Bundles in Patients with Agenesis of the Corpus Callosum},
	booktitle = {32nd Congress of the Europea Society of NeuroRadiolog},
	year = {2007},
	pages = {135},
	author = {Wim Van Hecke and Alexander Leemans and N. De Brabander and A. Laridon and K. Claeys and B. Ceulemans and J. Van Goethem and Paul M Parizel and Jan Sijbers}
}
@inproceedings {Parizelwvhecke2007,
	title = {Diffusion Tensor Imaging: Is it really useful?},
	booktitle = {32nd Congress of the Europea Society of NeuroRadiolog},
	year = {2007},
	author = {Paul M Parizel and Wim Van Hecke}
}
@inproceedings {wvheckealeemansjsijbersParizelGoethem2007,
	title = {Diffusion Tensor Tractoghraphy Reaveals Spinal Cord Alterations in Patients with Multiple Sclerosis},
	booktitle = {32nd Congress of the Europea Society of NeuroRadiolog},
	year = {2007},
	pages = {129},
	author = {Wim Van Hecke and Alexander Leemans and Jan Sijbers and Paul M Parizel and J. Van Goethem}
}
@article {ParizelRompaeyLoockwvheckeGoethemaleemansjsijbers2007,
	title = {Influence of User-Defined Parameters on Diffusion Tensor Tractography of the Corticospinal Tract},
	journal = {The Neuroradiology Journal},
	number = {20},
	year = {2007},
	pages = {139-147},
	author = {Paul M Parizel and V. Van Rompaey and R. Van Loock and Wim Van Hecke and J. Van Goethem and Alexander Leemans and Jan Sijbers}
}
@article {wvheckealeemansD{\textquoteright}AgostinosdbackerVandervlietParizeljsijbers2007,
	title = {Nonrigid Coregistration of Diffusion Tensor Images Using a Viscous Fluid Model and Mutual Information},
	journal = {IEEE Transactions on Medical Imaging},
	volume = {26},
	number = {11},
	year = {2007},
	pages = {1598-1612},
	author = {Wim Van Hecke and Alexander Leemans and E. Dagostino and Steve De Backer and Everhard Vandervliet and Paul M Parizel and Jan Sijbers}
}
@inproceedings {wvheckealeemansVandervlietParizeljsijbers2007,
	title = {An optimized tensor orientation strategy for non-rigid alignment of DT-MRI data},
	booktitle = {Joint Annual Meeting ISMRM-ESMRMB},
	year = {2007},
	address = {Berlin},
	author = {Wim Van Hecke and Alexander Leemans and Everhard Vandervliet and Paul M Parizel and Jan Sijbers}
}
@inproceedings {VandervlietNagelsHeineckewvheckealeemansjsijbersParizel2006,
	title = {On the cause and mechanisms of the negative BOLD response in fMRI},
	booktitle = {23rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology},
	year = {2006},
	pages = {308},
	address = {Warsaw, Poland},
	author = {Everhard Vandervliet and Guy Nagels and A. Heinecke and Wim Van Hecke and Alexander Leemans and Jan Sijbers and Paul M Parizel}
}
@inproceedings {wvheckealeemansjsijbersParizelGoethem2006,
	title = {A comparison of diffusion tensor analysis methods for detecting age-related changes of the normal appearing spinal cord},
	booktitle = {23rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology},
	year = {2006},
	pages = {293-294},
	address = {Warsaw, Poland},
	author = {Wim Van Hecke and Alexander Leemans and Jan Sijbers and Paul M Parizel and J. Van Goethem}
}
@inproceedings {wvheckealeemansBrabanderLaridonCeulemansJParizel2006,
	title = {Diffusion tensor fiber tracking in patients with agenesis of the corpus callosum},
	booktitle = {23rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology},
	year = {2006},
	pages = {34-35},
	address = {Warsaw, Poland},
	author = {Wim Van Hecke and Alexander Leemans and N. De Brabander and A. Laridon and B. Ceulemans and Jan Sijbers and Paul M Parizel}
}
@inproceedings {wvheckealeemansjsijbersParizelGoethem2006,
	title = {DTI of normal appearing spinal cord in elderly},
	booktitle = {44th Annual Meeting of the American Society of Neuroradiology},
	year = {2006},
	month = {May},
	pages = {380-381},
	address = {San Diego, USA},
	author = {Wim Van Hecke and Alexander Leemans and Jan Sijbers and Paul M Parizel and J. Van Goethem}
}
@inproceedings {NagelsVandervlietwvheckeEngelborghshoogheCrasParizelDeyn2006,
	title = {fMRI during PASAT and PVSAT in mild MS, moderate MS and normal volunteers.},
	booktitle = {22nd Congress of the European Committee for},
	year = {2006},
	address = {Madrid, Spain},
	author = {Guy Nagels and Everhard Vandervliet and Wim Van Hecke and Sebastiaan Engelborghs and M.B. D hooghe and P. Cras and Paul M Parizel and P.P. De Deyn}
}
@inproceedings {wvheckealeemanssdbackerVandervlietParizelAgostinojsijbers2006,
	title = {Multi-channel coregistration of diffusion tensor images based on a viscous fluid model},
	booktitle = {Belgian Day on Biomedical Engineering - IEEE/EMBS Benelux Symposium},
	year = {2006},
	pages = {139-142},
	address = {Brussels, Belgium},
	author = {Wim Van Hecke and Alexander Leemans and Steve De Backer and Everhard Vandervliet and Paul M Parizel and E. Dagostino and Jan Sijbers}
}
@inproceedings {BertelsthuysmanjsijbersVerdonkParizel2006,
	title = {Multi-scale registration of spherical parametrizations of the human cortex},
	booktitle = {23rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology},
	year = {2006},
	pages = {89},
	address = {Warsaw, Poland},
	author = {J. Bertels and Toon Huysmans and Jan Sijbers and B. Verdonk and Paul M Parizel}
}
@article {aleemansjsijberssdbackerVandervlietParizel2006,
	title = {Multiscale white matter fiber tract coregistration: a new feature-based approach to align diffusion tensor data},
	journal = {Magnetic Resonance in Medicine},
	volume = {55},
	number = {6},
	year = {2006},
	pages = {1414-1423},
	author = {Alexander Leemans and Jan Sijbers and Steve De Backer and Everhard Vandervliet and Paul M Parizel}
}
@inproceedings {aleemansjsijberssdbackerVandervlietParizel2006,
	title = {Multiscale white matter fiber tract coregistration: a new feature-based approach to align diffusion tensor data},
	booktitle = {14th Scientific Meeting - International Society for Magnetic Resonance in Medicine},
	year = {2006},
	pages = {437},
	address = {Seattle, USA},
	author = {Alexander Leemans and Jan Sijbers and Steve De Backer and Everhard Vandervliet and Paul M Parizel}
}
@inproceedings {wvheckealeemanssdbackerVandervlietParizeljsijbersAgostino2006,
	title = {Non-rigid coregistration of diffusion tensor images using a viscous fluid model.},
	booktitle = {23rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology},
	year = {2006},
	pages = {191-192},
	address = {Warsaw, Poland},
	author = {Wim Van Hecke and Alexander Leemans and Steve De Backer and Everhard Vandervliet and Paul M Parizel and Jan Sijbers and E. Dagostino}
}
@inproceedings {wvheckealeemansjsijbersParizelGoethem2006,
	title = {A preliminary study of diffusion tensor imaging and tractography of the spinal cord in elderly},
	booktitle = {21th Annual Symposium - Belgian Hospital Physicists Association},
	year = {2006},
	pages = {61},
	address = {Ghent, Belgium},
	author = {Wim Van Hecke and Alexander Leemans and Jan Sijbers and Paul M Parizel and J. Van Goethem}
}
@inproceedings {thuysmanBernatjsijbersParizelGlabbeekVerdonk2006,
	title = {Shape Analysis of the Human Clavicle for the Development of a Set of osteosynthesis Plates},
	booktitle = {Belgian Day on Biomedical Engineering - IEEE/EMBS Benelux Symposium},
	year = {2006},
	month = {December},
	pages = {128-129},
	address = {Brussels, Belgium},
	author = {Toon Huysmans and Amit Bernat and Jan Sijbers and Paul M Parizel and Francis Van Glabbeek and B. Verdonk}
}
@article {aleemansjsijberssdbackerVandervlietParizel2005,
	title = {Affine Coregistration of Diffusion Tensor Magnetic Resonance Images Using Mutual Information},
	journal = {Lecture Notes in Computer Science},
	volume = {3708},
	year = {2005},
	pages = {523-530},
	author = {Alexander Leemans and Jan Sijbers and Steve De Backer and Everhard Vandervliet and Paul M Parizel}
}
@article {ParizelGoethemHauweSalgadoVandervlietaleemans2005,
	title = {Characterization of brain tumors},
	journal = {NeuroRadiology},
	volume = {47},
	year = {2005},
	pages = {80-83},
	author = {Paul M Parizel and J. Van Goethem and L. van den Hauwe and R. Salgado and Everhard Vandervliet and Alexander Leemans}
}
@inproceedings {aleemanssdbackerjsijbersVandervlietParizel2005,
	title = {End point clustering for diffusion tensor white matter fiber bundle tractography},
	booktitle = {22th Annual Scientific Meeting - European Society for Magnetic Resonance in Medicine and Biology},
	year = {2005},
	pages = {129-130},
	address = {Basle, Switzerland},
	author = {Alexander Leemans and Steve De Backer and Jan Sijbers and Everhard Vandervliet and Paul M Parizel}
}
@inproceedings {aleemansjsijbersParizel2005,
	title = {A Graphical Toolbox for Exploratory Diffusion Tensor Imaging and Fiber Tractography},
	booktitle = {14th Annual Meeting - Section for Magnetic Resonance Technologists},
	year = {2005},
	address = {Miami, USA},
	author = {Alexander Leemans and Jan Sijbers and Paul M Parizel}
}
@inproceedings {aleemanssdbackerjsijbersVandervlietParizel2005,
	title = {TRACT: Tissue Relative Anisotropy based Curvature Thresholding for deterministic MR diffusion tensor tractography},
	booktitle = {22th Annual Scientific Meeting - European Society for Magnetic Resonance in Medicine and Biology},
	year = {2005},
	pages = {289},
	address = {Basle, Switzerland},
	author = {Alexander Leemans and Steve De Backer and Jan Sijbers and Everhard Vandervliet and Paul M Parizel}
}
