@article {1786,
	title = {The role of whole-brain diffusion MRI as a tool for studying human in vivo cortical segregation based on a measure of neurite density},
	journal = {Magnetic Resonance in Medicine},
	volume = {79},
	year = {2018},
	pages = {2738{\textendash}2744},
	keywords = {Brain, cortex, Diffusion MRI, fiber orientation distribution, myeloarchitecture, parcellation},
	issn = {1522-2594},
	doi = {10.1002/mrm.26917},
	url = {http://dx.doi.org/10.1002/mrm.26917},
	author = {Fernando Calamante and Ben Jeurissen and Robert Elton Smith and Tournier, Jacques-Donald and Connelly, Alan}
}
@article {1877,
	title = {Simulations of a Multipinhole SPECT Collimator for Clinical Dopamine Transporter (DAT) Imaging},
	journal = {IEEE Transactions on Radiation and Plasma Medical Sciences},
	volume = {2},
	year = {2018},
	month = {Sept},
	pages = {444-451},
	keywords = {Analytical models, Apertures, Brain, Collimators, Logic gates, multipinhole (MPH), Sensitivity, simulation, Single photon emission computed tomography, SPECT},
	issn = {2469-7311},
	doi = {10.1109/TRPMS.2018.2831208},
	author = {Arda K{\"o}nik and Jan De Beenhouwer and J. M. Mukherjee and Kesava Kalluri and S Banerjee and N Zeraatkar and Timothy J. Fromme and Michael A. King}
}
@article {1547,
	title = {Recursive calibration of the fiber response function for spherical deconvolution of diffusion MRI data.},
	journal = {NeuroImage},
	volume = {86},
	year = {2014},
	month = {2014 Feb 1},
	pages = {67-80},
	abstract = {There is accumulating evidence that at current acquisition resolutions for diffusion-weighted (DW) MRI, the vast majority of white matter voxels contains "crossing fibers", referring to complex fiber configurations in which multiple and distinctly differently oriented fiber populations exist. Spherical deconvolution based techniques are appealing to characterize this DW intra-voxel signal heterogeneity, as they provide a balanced trade-off between constraints on the required hardware performance and acquisition time on the one hand, and the reliability of the reconstructed fiber orientation distribution function (fODF) on the other hand. Recent findings, however, suggest that an inaccurate calibration of the response function (RF), which represents the DW signal profile of a single fiber orientation, can lead to the detection of spurious fODF peaks which, in turn, can have a severe impact on tractography results. Currently, the computation of this RF is either model-based or estimated from selected voxels that have a fractional anisotropy (FA) value above a predefined threshold. For both approaches, however, there are user-defined settings that affect the RF and, consequently, fODF estimation and tractography. Moreover, these settings still rely on the second-rank diffusion tensor, which may not be the appropriate model, especially at high b-values. In this work, we circumvent these issues for RF calibration by excluding "crossing fibers" voxels in a recursive framework. Our approach is evaluated with simulations and applied to in vivo and ex vivo data sets with different acquisition settings. The results demonstrate that with the proposed method the RF can be calibrated in a robust and automated way without needing to define ad-hoc FA threshold settings. Our framework facilitates the use of spherical deconvolution approaches in data sets in which it is not straightforward to define RF settings a priori.},
	keywords = {Adult, Algorithms, Brain, Calibration, diffusion tensor imaging, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Imaging, Three-Dimensional, Male, Nerve Fibers, Myelinated, Pattern Recognition, Automated, Reproducibility of Results, Sensitivity and Specificity},
	issn = {1095-9572},
	doi = {10.1016/j.neuroimage.2013.07.067},
	author = {Chantal M W Tax and Ben Jeurissen and Vos, Sjoerd B. and Viergever, Max A. and Alexander Leemans}
}
@article {1546,
	title = {Structural neuroimaging correlates of allelic variation of the BDNF val66met polymorphism.},
	journal = {NeuroImage},
	volume = {90},
	year = {2014},
	month = {2014 Apr 15},
	pages = {280-9},
	abstract = {BACKGROUND: The brain-derived neurotrophic factor (BDNF) val66met polymorphism is associated with altered activity dependent secretion of BDNF and a variable influence on brain morphology and cognition. Although a met-dose effect is generally assumed, to date the paucity of met-homozygotes have limited our understanding of the role of the met-allele on brain structure.

METHODS: To investigate this phenomenon, we recruited sixty normal healthy subjects, twenty in each genotypic group (val/val, val/met and met/met). Global and local morphology were assessed using voxel based morphometry and surface reconstruction methods. White matter organisation was also investigated using tract-based spatial statistics and constrained spherical deconvolution tractography.

RESULTS: Morphological analysis revealed an "inverted-U" shaped profile of cortical changes, with val/met heterozygotes most different relative to the two homozygous groups. These results were evident at a global and local level as well as in tractography analysis of white matter fibre bundles.

CONCLUSION: In contrast to our expectations, we found no evidence of a linear met-dose effect on brain structure, rather our results support the view that the heterozygotic BDNF val66met genotype is associated with cortical morphology that is more distinct from the BDNF val66met homozygotes. These results may prove significant in furthering our understanding of the role of the BDNF met-allele in disorders such as Alzheimer{\textquoteright}s disease and depression.},
	keywords = {Adolescent, Adult, Alleles, Brain, Brain-Derived Neurotrophic Factor, diffusion tensor imaging, Female, Genotype, Heterozygote, Homozygote, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Polymorphism, Single Nucleotide, Young Adult},
	issn = {1095-9572},
	doi = {10.1016/j.neuroimage.2013.12.050},
	author = {Forde, Natalie J and Ronan, Lisa and Suckling, John and Scanlon, Cathy and Neary, Simon and Holleran, Laurena and Alexander Leemans and Tait, Roger and Rua, Catarina and Fletcher, Paul C and Ben Jeurissen and Dodds, Chris M and Miller, Sam R and Bullmore, Edward T and Colm McDonald and Nathan, Pradeep J and Dara M. Cannon}
}
@article {1438,
	title = {Nonlocal maximum likelihood estimation method for denoising multiple-coil magnetic resonance images.},
	journal = {Magnetic resonance imaging},
	volume = {30},
	year = {2012},
	month = {2012 Dec},
	pages = {1512-8},
	abstract = {Effective denoising is vital for proper analysis and accurate quantitative measurements from magnetic resonance (MR) images. Even though many methods were proposed to denoise MR images, only few deal with the estimation of true signal from MR images acquired with phased-array coils. If the magnitude data from phased array coils are reconstructed as the root sum of squares, in the absence of noise correlations and subsampling, the data is assumed to follow a non central-χ distribution. However, when the k-space is subsampled to increase the acquisition speed (as in GRAPPA like methods), noise becomes spatially varying. In this note, we propose a method to denoise multiple-coil acquired MR images. Both the non central-χ distribution and the spatially varying nature of the noise is taken into account in the proposed method. Experiments were conducted on both simulated and real data sets to validate and to demonstrate the effectiveness of the proposed method.},
	keywords = {Algorithms, Animals, Brain, Brain Mapping, Computer Simulation, Fourier Analysis, Image Processing, Computer-Assisted, Likelihood Functions, Magnetic Resonance Imaging, Mice, Models, Statistical, Normal Distribution, Signal-To-Noise Ratio, Stochastic Processes},
	issn = {1873-5894},
	doi = {10.1016/j.mri.2012.04.021},
	author = {Jeny Rajan and Jelle Veraart and Johan Van Audekerke and Marleen Verhoye and Jan Sijbers}
}
@article {1189,
	title = {Noise measurement from magnitude MRI using local estimates of variance and skewness.},
	journal = {Physics in medicine and biology},
	volume = {55},
	year = {2010},
	month = {2010 Aug 21},
	pages = {N441-9},
	abstract = {In this note, we address the estimation of the noise level in magnitude magnetic resonance (MR) images in the absence of background data. Most of the methods proposed earlier exploit the Rayleigh distributed background region in MR images to estimate the noise level. These methods, however, cannot be used for images where no background information is available. In this note, we propose two different approaches for noise level estimation in the absence of the image background. The first method is based on the local estimation of the noise variance using maximum likelihood estimation and the second method is based on the local estimation of the skewness of the magnitude data distribution. Experimental results on synthetic and real MR image datasets show that the proposed estimators accurately estimate the noise level in a magnitude MR image, even without background data.},
	keywords = {Algorithms, Artifacts, Brain, Data Interpretation, Statistical, Fourier Analysis, Humans, Image Processing, Computer-Assisted, Likelihood Functions, Magnetic Resonance Imaging, Models, Statistical, Myocardium, Normal Distribution, Reproducibility of Results},
	issn = {1361-6560},
	doi = {10.1088/0031-9155/55/16/N02},
	author = {Jeny Rajan and Dirk H J Poot and Juntu, Jaber and Jan Sijbers}
}
@article {1374,
	title = {Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis: revisited.},
	journal = {Human brain mapping},
	volume = {30},
	year = {2009},
	month = {2009 Nov},
	pages = {3657-75},
	abstract = {Voxel-based analyses (VBA) are increasingly being used to detect white matter abnormalities with diffusion tensor imaging (DTI) in different types of pathologies. However, the validity, specificity, and sensitivity of statistical inferences of group differences to a large extent depend on the quality of the spatial normalization of the DTI images. Using high-dimensional nonrigid coregistration techniques that are able to align both the spatial and orientational diffusion information and incorporate appropriate templates that contain this complete DT information may improve this quality. Alternatively, a hybrid technique such as tract-based spatial statistics (TBSS) may improve the reliability of the statistical results by generating voxel-wise statistics without the need for perfect image alignment and spatial smoothing. In this study, we have used (1) a coregistration algorithm that was optimized for coregistration of DTI data and (2) a population-based DTI atlas to reanalyze our previously published VBA, which compared the fractional anisotropy and mean diffusivity maps of patients with amyotrophic lateral sclerosis (ALS) with those of healthy controls. Additionally, we performed a complementary TBSS analysis to improve our understanding and interpretation of the VBA results. We demonstrate that, as the overall variance of the diffusion properties is lowered after normalizing the DTI data with such recently developed techniques (VBA using our own optimized high-dimensional nonrigid coregistration and TBSS), more reliable voxel-wise statistical results can be obtained than had previously been possible, with our VBA and TBSS yielding very similar results. This study provides support for the view of ALS as a multisystem disease, in which the entire frontotemporal lobe is implicated.},
	keywords = {Adult, Aged, Algorithms, Amyotrophic Lateral Sclerosis, anisotropy, Brain, Brain Mapping, Case-Control Studies, diffusion tensor imaging, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Reproducibility of Results, Sensitivity and Specificity, Statistics as Topic},
	issn = {1097-0193},
	doi = {10.1002/hbm.20794},
	author = {Caroline A Sage and Wim Van Hecke and Ron R Peeters and Jan Sijbers and Robberecht, Wim and Paul M Parizel and Marchal, Guy and Alexander Leemans and Stefan Sunaert}
}
