NOVIFAST: A fast non-linear least squares method for accurate and precise estimation of T1 from SPGR signals

Abstract: 

The longitudinal relaxation time T1 can be estimated from a set of spoiled gradient recalled echo (SPGR) magnetic resonance images acquired over a range of flip angles with constant repetition time (TR). While linear estimators are widely used because of their low computation time, they are less accurate than their slower nonlinear counterpart. In this work, we introduce a novel NOn-linear VarIable Flip Angle data baSed T1 (NOVIFAST) estimator that combines the best of both worlds: high accuracy and precision in a low computation time.

This work is currently in review,

Ramos-Llordén, G., Vegas-Sánchez-Ferrero, G., Björk, M., Vanhevel, F., Parizel, P. M., San José Estépar, R., den Dekker, A. J., and Sijbers, J., "NOVIFAST: a fast algorithm for accurate and precise VFA MRI T1 mapping," IEEE Trans. Med. Imag., in review.

Source code will be available as soon as the paper is accepted

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