Diffusion MRI

We developed a super-resolution reconstruction methodology for diffusion and relaxometry MRI. It allows to improve the trade-off between acquisition time, spatial resolution and SNR. From a set of low resolution multi-slice images, each with a different (diffusion or relaxometry) contrast, an image is reconstructed with a much higher spatial resolution compared to a 3D image that is directly acquired in the same time frame.

Diffusion weighted magnetic resonance (DW-MR) imaging suffers from physiological noise such as artifacts caused by motion or system instabilities. This obviates the need for robust diffusion parameter estimation techniques. In the past, several techniques have been presented including RESTORE and iRESTORE. However, these techniques are based on nonlinear estimators, and are consequently computationally intensive. We present a new robust, iteratively reweighted linear least squares (IRLLS) estimator.