Effect of diffusion time dependence on parameter estimation in the clinical time frame: a simulation study using PGSE

Publication Type:

Conference Abstract


11th Annual Meeting of the ISMRM Benelux Chapter, Leiden, the Netherlands (2019)


Fieremans et al. modelled the diffusion time dependence of diffusion longitudinal and transverse to white matter tracts, which can be interpreted as an effect of structural disorder at the mesoscopic scale. To our knowledge, this diffusion time-dependent (DT-dependent) model has not yet been studied in the mid-time regime (Δ=20-180ms) with varying echo times, which would be valuable for clinical practice. In this simulation study, we use the pulsed-gradient spin-echo (PGSE) sequence5 and study the effects of varying the diffusion time on the parameter estimation in a mid-time regime.