Theoretical study of the free water elimination model

Publication Type:

Conference Abstract


7th Annual Meeting of the Benelux ISMRM Chapter, Ghent, Belgium, p.78 (2015)


Partial volume effects caused by cerebrospinal fluid are an important issue in diffusion MRI. In this work, we study the free water elimination model by analyzing the Cramér-Rao lower bound (CRLB) of its parameters. We show that through optimizing the acquisition protocol by minimizing the trace of the CRLB, a significant gain in the precision of the parameter estimation can be achieved. Moreover, further analysis indicates that regularization and/or constraints are necessary for parameter estimation from voxels with large CSF fractions and/or low FA values. These theoretical findings are confirmed by both simulation and real data experiments.