High angular resolution diffusion-weighted imaging in mild traumatic brain injury

TitleHigh angular resolution diffusion-weighted imaging in mild traumatic brain injury
Publication TypeJournal Article
Year of Publication2017
AuthorsMohammadian, M., T. Roine, J. Hirvonen, T. Kurki, H. Ala-Seppälä, J. Frantzén, A. Katila, A. Kyllönen, H-R. Maanpää, J. Posti, R. Takala, J. Tallus, and O. Tenovuo
JournalNeuroImage: Clinical
Pagination174 - 180
Date Published11/2016
KeywordsDiffusion-weighted magnetic resonance imaging, Global approach, Magnetic Resonance Imaging, probabilistic tractography, Traumatic brain injury

We sought to investigate white matter abnormalities in mild traumatic brain injury (mTBI) using diffusion-weighted magnetic resonance imaging (DW-MRI). We applied a global approach based on tract-based spatial statistics skeleton as well as constrained spherical deconvolution tractography. DW-MRI was performed on 102 patients with mTBI within two months post-injury and 30 control subjects. A robust global approach considering only the voxels with a single-fiber configuration was used in addition to global analysis of the tract skeleton and probabilistic whole-brain tractography. In addition, we assessed whether the microstructural parameters correlated with age, time from injury, patient's outcome and white matter \{MRI\} hyperintensities. We found that whole-brain global approach restricted to single-fiber voxels showed significantly decreased fractional anisotropy (FA) (p = 0.002) and increased radial diffusivity (p = 0.011) in patients with mTBI compared with controls. The results restricted to single-fiber voxels were more significant and reproducible than those with the complete tract skeleton or the whole-brain tractography. \{FA\} correlated with patient outcomes, white matter hyperintensities and age. No correlation was observed between \{FA\} and time of scan post-injury. In conclusion, the global approach could be a promising imaging biomarker to detect white matter abnormalities following traumatic brain injury.