Theoretical study of the free water elimination model

TitleTheoretical study of the free water elimination model
Publication TypeConference Abstract
Year of Publication2015
AuthorsCollier, Q., J. Veraart, B. Jeurissen, A J. den Dekker, and J. Sijbers
Conference NameISMRM 23th Annual Meeting, Toronto, Ontario, Canada

Partial volume effects caused by cerebrospinal fluid are an important issue in diffusion MRI. In this work, we study the free water elimination model by analyzing the Cramér-Rao lower bound (CRLB) of its parameters. We show that through optimizing the acquisition protocol by minimizing the trace of the CRLB, a significant gain in the precision of the parameter estimation can be achieved. Moreover, further analysis indicates that regularization and/or constraints are necessary for parameter estimation from voxels with large CSF fractions and/or low FA values. These theoretical findings are confirmed by both simulation and real data experiments.